Return to Bryona in Cerrigar

Speak with Bryona to Diablo 4 Items hand over the Blood Relic.
This completes Bearing the Weight of Ghosts.

You will either:

Move on to the next quest: Keepers of the Glen, if you have enough seasonal rep.
Or return to The Truth That Lies Within, to keep farming rep until it unlocks.

Summary: Bearing the Weight of Ghosts Checklist

1. Complete The Truth That Lies Within
2. Gain enough reputation to unlock the next quest
3. Enter a Nightmare Dungeon with a Strongroom affix
4. Clear the Horadric Strongroom and defeat Agony
5. Loot the Blood Relic from the chest
6. Return to Bryona in Cerrigar

Tips for Efficient Completion

Stockpile Nightmare Sigils with the Horadric Strongroom affix.
Clear dungeons efficiently using movement and AOE skills.
Prioritize buffs that improve speed and survivability.
Keep an eye on your Seasonal Journal rep meter to avoid delays in quest unlocking.

Bearing the Weight of Ghosts is the first true test in Season 9's main story. It takes you deeper into Horadric Strongrooms, forces you to face upgraded mini-boss mechanics, and ties your seasonal reputation directly to buy Diablo IV Items story progress.